West Virginia 37, Kansas State 10
Jarret Doege threw for 301 yards and two touchdowns as West Virginia handed No. 16 Kansas State its first Big 12 loss in a 37-10 upset on Saturday in Morgantown, W.Va.
Clemson 34, Boston College 28
Freshman quarterback D.J. Uiagalelei passed for 342 yards and two touchdowns and ran for a third as No. 1 Clemson survived a scare from Boston College before holding on for a 34-28 victory Saturday afternoon at Clemson's Memorial Stadium.
Iowa State 52, Kansas 22
Breece Hall rushed for 185 yards and two touchdowns Saturday, Brock Purdy added 239 yards passing as No. 23 Iowa State stomped Kansas 52-22 at Lawrence, Kan.
Coastal Carolina 51, Georgia St. 0
Grayson McCall threw four touchdown passes in his return to action as No. 20 Coastal Carolina blasted host Georgia State 51-0 on Saturday afternoon in Atlanta.
Cincinnati 49, Memphis 10
Junior quarterback Desmond Ridder accounted for a career-high five touchdowns and the Bearcats' defense smothered visiting Memphis throughout as No. 7 Cincinnati rolled to a 49-10 win on Saturday afternoon at Nippert Stadium.
Tulane 38, Temple 3
Michael Pratt threw two touchdown passes and ran for a third score as host Tulane routed short-handed Temple 38-3 in an American Athletic Conference game Saturday.
Florida Atlantic 24, Texas-San Antonio 3
Nick Tronti passed for one touchdown and ran for another as the host Florida Atlantic Owls defeated the Texas-San Antonio Roadrunners 24-3 on Saturday afternoon at Boca Raton, Fla.
Wake Forest 38, Syracuse 14
Kenneth Walker III rushed for three touchdowns as visiting Wake Forest posted a 38-14 victory over Syracuse on Saturday in an Atlantic Coast Conference game.
Georgia 14, Kentucky 3
Zamir White rushed for a career-high 136 yards with a touchdown, and No. 5 Georgia beat Kentucky 14-3 on Saturday in an SEC contest at Lexington, Ky.
Purdue 31, Illinois 24
Aidan O'Connell threw for 376 yards and two touchdowns as Purdue held off undermanned Illinois, 31-24, in a Big Ten matchup on Saturday in Champaign, Ill.
Michigan State 27, Michigan 24
Rocky Lombardi threw three touchdown passes, two to Connor Heyward, and Michigan State stunned No. 13 Michigan 27-24 in Big Ten action on Saturday in Ann Arbor, Mich.
Central Florida 44, Houston 21
UCF unleashed the nation's top-ranked offense on host Houston, amassing 681 yards while cruising to a 44-21 victory on Saturday in an American Athletic Conference game.
Texas Christian 33, Baylor 23
Freshman running back Darwin Barlow rushed for 117 yards and a touchdown to lead TCU to a 33-23 win at Baylor in a Big 12 contest on Saturday.
Notre Dame 31, Georgia Tech 13
Ian Book threw for 199 yards and one touchdown and Kyren Williams ran for two touchdowns to help No. 4 Notre Dame to a 31-13 win over Georgia Tech on Saturday in Atlantic Coast Conference play at Atlanta.
Auburn 48, Louisiana State 11
Bo Nix threw three touchdown passes and ran for another as host Auburn breezed to a 48-11 victory over LSU on Saturday in a Southeastern Conference game.
Indiana 37, Rutgers 21
Michael Penix Jr. passed for three touchdowns and ran for another, and No. 17 Indiana was able to seal a 37-21 victory when a stunning eight-lateral touchdown from Rutgers was overturned Saturday in Piscataway, N.J.
Northwestern 21, Iowa 20
The Northwestern Wildcats came back from a 17-point first-half deficit to defeat the host Iowa Hawkeyes on Saturday, 21-20.
Mississippi 54, Vanderbilt 21
Ole Miss quarterback Matt Corral and wide receiver Elijah Moore shattered school records as the Rebels obliterated Vanderbilt in a 54-21 win at Nashville's Vanderbilt Stadium on Saturday afternoon.
Virginia Tech 42, Louisville 35
Hendon Hooker complemented a perfect passing performance with three rushing touchdowns, and Khalil Herbert capped his 147-yard rushing afternoon with a 24-yard touchdown run that sealed Virginia Tech's 42-35 win over host Louisville in Atlantic Coast Conference play on Saturday.
Texas 41, Oklahoma State 34
Texas quarterback Sam Ehlinger hit Joshua Moore with a 15-yard touchdown pass in overtime and the Longhorns' defense kept No. 6 Oklahoma State out of the end zone to complete a 41-34 win on Saturday in a key Big 12 game in Stillwater, Okla.
Boise State 49, Air Force 30
Jack Sears passed for 280 yards and three touchdowns and also rushed for one score during a surprise starting assignment to lead No. 25 Boise State to a 49-30 victory over Air Force on Saturday in Mountain West play on the academy grounds just outside Colorado Springs, Colo.
Duke 53, Charlotte 19
Running backs Deon Jackson and Mataeo Durant each ran for two touchdowns as Duke topped visiting Charlotte 53-19 on Saturday night at Wallace Wade Stadium in Durham, N.C.
Alabama 41, Mississippi State 0
In a battle of the SEC's top-ranked offense and top-ranked defense, both Alabama units were too much for Mississippi State in the No. 2 Crimson Tide's 41-0 win over the Bulldogs on Saturday night in Tuscaloosa, Ala.
Texas A&M 42, Arkansas 31
Senior quarterback Kellen Mond threw three touchdown passes, including a pair to tight end Jalen Wydermyer, to lead the host Texas A&M Aggies to a 42-31 win over the Arkansas Razorbacks on Saturday night in the annual Southwest Classic.
Southern Methodist 51, Navy 37
A week after playing the bug, No. 22-ranked SMU reversed roles and played the windshield against Navy on Saturday.
Ohio State 38, Penn State 25
Justin Fields threw for 318 yards and four touchdowns and No. 3 Ohio State defeated No. 18 Penn State 38-25 at Beaver Stadium in University Park, Pa., on Saturday.
Florida 41, Missouri 17
Kyle Trask threw four touchdowns and Kadarius Toney scored three times to spark No. 10 Florida to a 41-17 victory against Missouri on Saturday night in a game marred by a halftime skirmish between the teams at Gainesville, Fla.
Virginia 44, North Carolina 41
Brennan Armstrong threw for three touchdowns and ran for a fourth Saturday night as Virginia upset No. 15 North Carolina 44-41 in an Atlantic Coast Conference contest at Scott Stadium in Charlottesville, Va.
Oklahoma 62, Texas Tech 28
Rhamondre Stevenson ran for three touchdowns in his first game of the season as No. 24 Oklahoma blew out Texas Tech 62-28 at Lubbock, Texas.
Brigham Young 41, Western Kentucky 10
Zach Wilson threw three touchdown passes and ran for another score and No. 11 BYU scored touchdowns on all five of its first-half possessions while cruising to a 41-10 victory over Western Kentucky on Saturday night in Provo, Utah.